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Trulicity (Dulaglutide): 13 Pharmacist-Verified Answers to Key Questions About the Diabetes Medication

Pharmacist-Verified Information on the Effects, Side Effects, and Use of Trulicity and Its Active Ingredient Dulaglutide

Trulicity (Dulaglutide) is approved by the European Medicines Agency (EMA). It is once-weekly injectable medication designed to lower blood sugar levels. It stimulates insulin production when blood sugar rises and slows digestion to regulate post-meal blood sugar spikes. Trulicity also reduces sugar production in the liver. Since it is only a once-weekly injection, it helps facilitate adherence to treatment.

Overtime it helps lower HbA1c levels and may reduce the risk of cardiovascular events in adults with type 2 diabetes and pre-existing heart disease. Many patients also report weight loss. Trulicity reduces appetite and slows digestion, which can contribute to weight reduction. Unlike insulin, which is taken with meals, Trulicity works independently of food intake.

The content on this page is provided for informational purposes only. If you have any questions or concerns about your treatment, you should talk to your doctor, pharmacist, or healthcare professional. This is particularly important if you are taking multiple medications or have any existing medical conditions.

What is Trulicity?

Trulicity is a once-weekly injectable medication for blood sugar control in adults with type 2 diabetes. It belongs to the class of GLP-1 receptor agonists, also known as incretin mimetics.

Who is Trulicity suitable for?

Trulicity is intended for adults with type 2 diabetes to improve blood sugar control. It is not recommended for individuals with type 1 diabetes or certain thyroid disorders.

How does Trulicity work?

Trulicity mimics a hormone that stimulates insulin production, slows digestion, and reduces sugar production in the liver to maintain stable blood sugar levels.

How is Trulicity used?

Trulicity is injected subcutaneously (under the skin) once a week using a prefilled pen. The injection can be administered in the abdomen, thigh, or upper arm at any time of the day. The built-in autoinjector simplifies application.

What are the most common side effects of Trulicity?

Some patients may experience the following side effects:

  • Nausea (often improves over time)
  • Vomiting
  • Diarrhea
  • Reduced appetite
  • Abdominal pain

💡 If side effects persist or worsen, consult your doctor.

Does Trulicity help with weight loss?

Yes, although Trulicity is not primarily a weight-loss drug, many patients report weight reduction due to decreased appetite and slower digestion. This can lead to sustained weight loss, including a reduction in abdominal fat. Initial changes may become noticeable after 4 to 6 weeks of regular use.

How long does it take for Trulicity to work?

Patients may notice initial improvements in blood sugar levels within few weeks. A significant reduction in HbA1c levels has been observed after six months, with further progress after one year.

Is Trulicity the same as Ozempic?

No, while Trulicity and Ozempic belong to the same class of medications (GLP-1 receptor agonists), they contain different active ingredients (Dulaglutide for Trulicity, Semaglutide for Ozempic). Both work similarly but may have different effects.

Is Trulicity Insulin?

No, Trulicity is not insulin. It regulates insulin production but does not replace insulin therapy for those who require it.

Which foods should be avoided while taking Trulicity?

It is advisable to avoid:

  • Fatty foods
  • Fried foods
  • High-fat meals

💡 These can exacerbate nausea and digestive issues. A balanced diet can help make Trulicity therapy more tolerable and is generally recommended for diabetes management.

Is there a natural alternative to Trulicity?

💡 Natural alternatives include a healthy diet, regular exercise, and weight management.

Which medications should not be taken with Trulicity?

Certain medications, such as insulin or sulfonylureas, may increase the risk of hypoglycemia when combined with Trulicity. Always consult your doctor before taking new medications.

Which Apps can support My Trulicity Therapy?

Apps like MyTherapy can help monitor your progress. They assist in medication reminders, tracking blood sugar levels, and managing weight.


The content on this page is provided for informational purposes only. If you have any questions or concerns about your treatment, you should talk to your doctor, pharmacist, or healthcare professional. This is particularly important if you are taking multiple medications or have any existing medical conditions.